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The pairing matters

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In nonadipose tissues with high rates of TG hydrolysis, such as skeletal muscle and liver, regulation of ATGL activity occurs via a mechanism distinct from that in adipose tissues

cruzi G6PD, lacking 57 N-terminal and ten C-terminal residues ( Tc G6PDH), with G6P and NADPH (PDB entry 5aq1) revealed the presence of a cavity near the catalytic NADPH binding site which is not present in the human enzyme

However, it is noteworthy that GH receptors are present in the proximal tubule, a site where IGF-I mRNA is not normally expressed, suggesting that GH also may have direct actions on tubular function[364]